Prednisone and diclofenac.
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Prednisone (Oral Route) Precautions - Mayo Clinic. |
Prednisone and diclofenac
Postoperative discomfort, redness, best-corrected visual acuity BCVA , signs of inflammation and intraocular pressure IOP were assessed at each visit. To assess postoperative discomfort or pain, a visual linear point pain scale was usedon which patients were asked to indicate their discomfort or pain on a scale from 0 no pain to 10 maximum pain. Results: Ninety-eight eyes 98 patients completed the study. The mean age of the 40 men and 48 women was Diclofenac patients reported significant less postoperative discomfort.
Patients on diclofenac resulted in faster wound healing. Conclusions: Diclofenac may be as effective and as safe as prednisolone in controlling postoperative inflammation whitout having the side effects of prednisolone. Purchase this article with an account.
Commercial Relationships A. Voudouri, None; P. Zafirakis, None; G. Livir-Rallatos, None; C. Canakis, None; N. Markomichelakis, None. Alerts User Alerts. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:.
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for unwanted effects. Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.
Measure the concentrated liquid with the special oral dropper that comes with the package. If you use this medicine for a long time, do not suddenly stop using it without checking first with your doctor. You may need to slowly decrease your dose before stopping it completely.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. If you will be taking this medicine for a long time, it is very important that your doctor check you at regular visits for any unwanted effects that may be caused by this medicine. Blood or urine tests may be needed to check for unwanted effects. Using this medicine while you are pregnant can harm your unborn baby.
Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. If you are using this medicine for a long time, tell your doctor about any extra stress or anxiety in your life, including other health concerns and emotional stress.
Your dose of this medicine might need to be changed for a short time while you have extra stress. Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems.
Talk to your doctor right away if you have more than one of these symptoms while you are using this medicine: blurred vision, dizziness or fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness.
This medicine may cause you to get more infections than usual. Avoid people who are sick or have infections and wash your hands often. If you are exposed to chickenpox or measles, tell your doctor right away. If you start to have a fever, chills, sore throat, or any other sign of an infection, call your doctor right away. Check with your doctor right away if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment.
Your doctor may want you to have your eyes checked by an ophthalmologist eye doctor. While you are being treated with prednisone, do not have any immunizations vaccines without your doctor's approval.
Prednisone may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you.
Some examples of live vaccines include measles, mumps, influenza nasal flu vaccine , poliovirus oral form , rotavirus, and rubella.
Do not get close to them and do not stay in the same room with them for very long. If you have questions about this, talk to your doctor. This medicine may cause changes in mood or behavior for some patients. Tell your doctor right away if you have depression, mood swings, a false or unusual sense of well-being, trouble with sleeping, or personality changes while taking this medicine.
This medicine might cause thinning of the bones osteoporosis or slow growth in children if used for a long time. Tell your doctor if you have any bone pain or if you have an increased risk for osteoporosis. If your child is using this medicine, tell the doctor if you think your child is not growing properly.
Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain skin tests.
❿Prednisone and diclofenac.
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ANOVA was used to analyze these data. Conclusion: It was determined that the combination of a single dose of prednisolone and diclofenac is well-suited to the treatment of postoperative pain, trismus, and swelling after dental surgical procedures and should be used when extensive postoperative swelling of soft tissue is anticipated.
Single, oral dose of 50 mg diclofenac potassium pre-medication 1 hour before starting endodontic treatment. Non-steroidal anti-inflammatory drug as a preoperative medication.
Placebo tablet 1 hour before starting endodontic treatment. Outcome Measures. Primary Outcome Measures : Change in the intensity of post-endodontic pain [ Time Frame: Immediately after treatment completion; and at 6, 12, 24, and 48 hours post-operatively ] Pain intensity will be evaluated using visual analogue scale. Other Outcome Measures: Change in the incidence of post-endodontic pain [ Time Frame: Immediately after treatment completion; and at 6, 12, 24, and 48 hours post-operatively ] Pain incidence will be evaluated using visual analogue scale.
Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Inclusion Criteria: Age between years. Males and females.
American Society of Anesthesiologists class 1 or 2. Patients who had not taken any anti-inflammatory drugs the day of the root canal procedure unless they belong to one of the intervention groups. Teeth other than single-rooted teeth. Radiographic evidence of external or internal root resorption vertical root fracture, perforation, or calcification. Immature teeth. Unrestorable teeth or teeth with severe periodontal disease.
Patients with a known allergy, sensitivity, or history of other adverse reactions to the medications administered. Patients with a history of active peptic ulcer within the preceding 12 months, bleeding problems, anticoagulant use within the last month, or kidney disease. Pregnant or nursing females. Patients who are unable to provide informed consent.
Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for unwanted effects.
Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. Measure the concentrated liquid with the special oral dropper that comes with the package. If you use this medicine for a long time, do not suddenly stop using it without checking first with your doctor. You may need to slowly decrease your dose before stopping it completely.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. If you will be taking this medicine for a long time, it is very important that your doctor check you at regular visits for any unwanted effects that may be caused by this medicine.
Blood or urine tests may be needed to check for unwanted effects. Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. If you are using this medicine for a long time, tell your doctor about any extra stress or anxiety in your life, including other health concerns and emotional stress.
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Study record managers: refer to the Data Element Definitions if submitting registration or results information. To assess the effect of using diclofenac potassium versus prednisolone as a pre-medication compared to placebo on:. After confirming the diagnosis and making sure that the patient conforms to all eligibility criteria, the principal investigator will enroll the patient in the study.
Intervention Group 2 Prednisolone : single, oral dose of 30 mg prednisolone one and a half tablets Solupred oro 20 mg, ARE, Aventis Intercontinental, Paris, France 30 min before starting endodontic treatment.
Control Group Placebo : The patients assigned to this group will be given a placebo tablet Starch, Bridgewater, NJ one hour before starting endodontic treatment. The participants will be blinded to the study hypothesis as to which intervention is expected to be better.
The patients, who already do not know their treatment group, will assess the level of their post-endodontic pain. Resource links provided by the National Library of Medicine MedlinePlus related topics: Potassium Drug Information available for: Prednisolone Prednisolone acetate Methylprednisolone acetate Methylprednisolone Prednisolone sodium phosphate Potassium bicarbonate Prednisolone phosphate Prednisolone sodium succinate Methylprednisolone sodium succinate Potassium chloride Diclofenac sodium Diclofenac potassium Diclofenac U.
Drug: Prednisolone 30 mg Steroidal anti-inflammatory drug as a preoperative medication Other Name: One and a half tablets Solupred oro 20 mg, ARE, Aventis Intercontinental, Paris, France Experimental: Diclofenac potassium premedication Single, oral dose of 50 mg diclofenac potassium pre-medication 1 hour before starting endodontic treatment. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. We're building a better ClinicalTrials. Check it out and tell us what you think! Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms. Save this study. Warning You have reached the maximum number of saved studies Effect of Diclofenac Potassium Versus Prednisolone on Post-endodontic Pain and Pulpal IL-8 Expression The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Recruitment status was: Not yet recruiting First Posted : October 30, Last Update Posted : October 30, View this study on Beta. Study Description. To assess the effect of using diclofenac potassium versus prednisolone as a pre-medication compared to placebo on: Intensity of post-endodontic pain in patients with symptomatic irreversible pulpitis.
Pulpal IL-8 expression. Incidence of post-endodontic pain in patients with symptomatic irreversible pulpitis. Show detailed description. Hide detailed description. Detailed Description:. Patients will be asked to rate their pre-operative pain intensity ie, before the commencement of any treatment [baseline score]; on the visual analogue scale "VAS" Enrolled patients will be randomly assigned into one of three groups: Intervention Group 1 Diclofenac Potassium : single, oral dose of 50 mg diclofenac potassium pre-medication Cataflam; NOVARTIS Pharma, Basel, Switzerland one hour before starting endodontic treatment.
After anesthesia is achieved and verified with Endo-Ice, the patient's tooth is isolated with a rubber dam, caries is excavated, and the pulp is exposed with a sterile round bur. Preparation of access cavity using a sterile round carbide bur and an Endo-Z bur Sample Collection: Blood from the exposed surface of the pulp will be collected with 2 sterile cotton pellets. The pellets will be held at the exposure site for seconds to allow absorption of the blood from the pulpal tissue.
The pellets will be placed in 1. After the pulpal blood sample is collected, patency of the root canals will be confirmed using stainless steel hand K-files sizes 10 and Working length will be determined using an electronic apex locator then confirmed radiographically to be 1 mm shorter than radiographic apex. Mechanical preparation will be completed in a crown down technique with ProTaper Next10 rotary files set on an endodontic motor adjusted at a speed of rpm and torque of gcm.
In-and-out motions will be applied with stroke lengths not exceeding 3mm in the cervical, middle, and apical thirds until attaining the established WL. The root canal will be thoroughly irrigated with 3 mL of 2. The canal will then be dried using sterile paper points.
Master cone fit radiograph will be taken and then the root canal will be obturated at the same appointment with matching-size gutta percha points and resin-based sealer using cold lateral compaction technique. Access cavity will be sealed with Coltosol F temporary filling material. At the end of the session, each patient will be instructed to complete a pain diary, VASat specific intervals; immediately after treatment completion; and 6, 12, 24, and 48 hours after the completion of treatment.
The patient will be asked to mark the level of pain on this cm line. The distance from the left end to the mark made by the patient, which will be measured by the operator with a ruler, is the pain intensity.
Patients will be contacted by their operator at each time-point to check on them and as a reminder. Then, information will be documented. Drug Information available for: Prednisolone Prednisolone acetate Methylprednisolone acetate Methylprednisolone Prednisolone sodium phosphate Potassium bicarbonate Prednisolone phosphate Prednisolone sodium succinate Methylprednisolone sodium succinate Potassium chloride Diclofenac sodium Diclofenac potassium Diclofenac. FDA Resources. Arms and Interventions.
Steroidal anti-inflammatory drug as a preoperative medication. Single, oral dose of 50 mg diclofenac potassium pre-medication 1 hour before starting endodontic treatment. Non-steroidal anti-inflammatory drug as a preoperative medication. Placebo tablet 1 hour before starting endodontic treatment. Outcome Measures. Primary Outcome Measures : Change in the intensity of post-endodontic pain [ Time Frame: Immediately after treatment completion; and at 6, 12, 24, and 48 hours post-operatively ] Pain intensity will be evaluated using visual analogue scale.
Other Outcome Measures: Change in the incidence of post-endodontic pain [ Time Frame: Immediately after treatment completion; and at 6, 12, 24, and 48 hours post-operatively ] Pain incidence will be evaluated using visual analogue scale. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Inclusion Criteria: Age between years. Males and females. American Society of Anesthesiologists class 1 or 2.
Patients who had not taken any anti-inflammatory drugs the day of the root canal procedure unless they belong to one of the intervention groups. Teeth other than single-rooted teeth. Radiographic evidence of external or internal root resorption vertical root fracture, perforation, or calcification. Immature teeth. Unrestorable teeth or teeth with severe periodontal disease. Patients with a known allergy, sensitivity, or history of other adverse reactions to the medications administered.
Patients with a history of active peptic ulcer within the preceding 12 months, bleeding problems, anticoagulant use within the last month, or kidney disease. Pregnant or nursing females. Patients who are unable to provide informed consent. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.
More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Symptomatic Irreversible Pulpitis. Phase 4. Study Type :. Interventional Clinical Trial. Estimated Enrollment :.
In this proposed study, the participant, and the assessor will be blinded. The laboratory technician at the microbiological department will not know the treatment group of the patients. The treatment groups will remain anonymous at the end of the study during assessment by the statistician. Estimated Study Start Date :. Estimated Primary Completion Date :. Estimated Study Completion Date :. Experimental: Prednisolone premedication Single, oral dose of 30 mg prednisolone pre-medication 30 min before starting endodontic treatment.
Experimental: Diclofenac potassium premedication Single, oral dose of 50 mg diclofenac potassium pre-medication 1 hour before starting endodontic treatment.
Placebo Comparator: Placebo Placebo tablet 1 hour before starting endodontic treatment. Drug: Placebo Starch. October 30, Key Record Dates.
It was determined that the combination of a single dose of prednisolone and diclofenac is well-suited to the treatment of postoperative pain, trismus. The combination of diclofenac and prednisolone is well suited to the treatment of postoperative pain, trismus, and swelling after dental surgical procedures. Objective:To compare diclofenac sodium with prednisolone acetate for the control of postoperative inflammation after cataract surgery. Conclusions: Diclofenac may be as effective and as safe as prednisolone in controlling postoperative inflammation whitout having the side effects of. To assess the effect of using diclofenac potassium versus prednisolone as a pre-medication compared to placebo on: Intensity of post-endodontic pain in. Drug: Placebo Starch. All rights reserved. Federal Government. Study Description.Purpose: The purpose of this study was to evaluate the effect of a single intramuscular dose of prednisolone and the prednisolone-diclofenac combination on postoperative pain, trismus, and edema after the removal of third molars. Patients and methods: Forty-five patients who were to undergo surgical removal of lower third molars were studied.
Patients were divided into 3 groups. In the first group, each patient was given 25 mg prednisolone intramuscularly immediately after surgery. In the second group, each patient was given 25 mg prednisolone and diclofenac intramuscularly immediately after surgery, and in the third group, each patient was given sterile saline solution as control group.
Postoperative pain was evaluated by visual analogue scale on the day of surgery. Facial swelling and trismus were evaluated on postoperative days 2 and 7. ANOVA was used to analyze these data.
Conclusion: It was determined that the combination of a single dose of prednisolone and diclofenac is well-suited to the treatment of postoperative pain, trismus, and swelling after dental surgical procedures and should be used when extensive postoperative swelling of soft tissue is anticipated. Abstract Purpose: The purpose of this study was to evaluate the effect of a single intramuscular dose of prednisolone and the prednisolone-diclofenac combination on postoperative pain, trismus, and edema after the removal of third molars.
Publication types Randomized Controlled Trial.
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