Deflazacort--an alternative to prednisolone?
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Alternative to prednisone.Any alternatives for Prednisone |
Top prednisone alternatives and how to switch your Rx.Is There An Alternative To Prednisone?
Compare prednisone alternatives Dexamethasone Methotrexate Mycophenolate Mercaptopurine Azathioprine Leflunomide Natural alternatives How to switch meds.
While the immune system defends our body from infections and cancer, it can also cause health problems if not regulated properly. Common diseases that arise from improper immune activity include inflammatory and autoimmune diseases. Prednisone can cause troublesome side effects in the short term, such as fluid retention, round face moon faceincreased risk of infection, high blood pressure, cortisol insufficiency, and others.
These side effects may be particularly problematic for patients who have pre-existing risks or health conditions such as osteoporosis, heart failure, hypertension, diabetes, glaucoma, or cataracts.
Despite its side effects, prednisone is an effective treatment for many diseases and might not always have a suitable replacement. In many cases, however, an adjunct agent can be used with prednisone to reduce the strength and duration of prednisone therapy. This article will discuss prednisone alternatives and steroid-sparing treatments that can reduce the dose of prednisone for patients with specific conditions.
The table below lists common therapies that can replace prednisone or can be used as an adjunct therapy to reduce the cumulative dose of prednisone. Some common uses, side effects, and dosing regimens are listed for each agent. Other corticosteroid-responsive conditions: 0. Transplant rejection: 0. Rheumatic disorders: 0. Heart or liver transplant: 1.
SLE: Loading dose of mg by mouth daily x 3 days. Juvenile idiopathic arthritis: mg by mouth once daily based on weight Leflunomide coupons Other alternatives to prednisone Remicade infliximab Enbrel etanercept Humira adalimumab Tocilizumab Dupixent dupilumab for severe asthma Fasenra benralizumab Cinqair reslizumab Xolair omalizumab Lupkynis voclosporin NSAIDs Patients with arthritis may be able to use NSAIDs instead of prednisone if their disease activity is not too severe.
NSAIDs are not as effective as steroids for the treatment of arthritis, but if symptoms are adequately controlled with NSAIDs, patients may not need to take oral corticosteroids. Common over-the-counter anti-inflammatory drugs for arthritis include ibuprofennaproxenand diclofenac gel. It is important to seek advice from your pharmacist or healthcare provider when using over-the-counter treatments in conjunction with prescriptions as certain drug interactions may occur.
Dexamethasone is a suitable alternative to prednisone for the treatment of acute asthma. In general, dexamethasone is better tolerated and requires a shorter course of therapy five days of prednisone versus one to five days of dexamethasone. Dexamethasone is approximately six times as potent as prednisone, and a single dose is longer acting.
Therefore, fewer doses are required compared with prednisone. A study in showed that two days of dexamethasone had similar efficacy to five days of prednisone and patients on dexamethasone had better compliance and fewer side effects. A study in also demonstrated that two doses of dexamethasone are as effective as five days of prednisone in children with asthma exacerbation admitted to the emergency department.
A meta-analysis in concludes that dexamethasone is associated with less vomiting compared to prednisone when used for asthma exacerbations. Finally, dexamethasone is available in more dosage forms than prednisone.
While prednisone is only available as an oral tablet, dexamethasone is available as a tablet or solution, and can be injected via the intravenous, subcutaneous, or intramuscular route. Methotrexate is used as a steroid-sparing agent for many diseases. It is common to use DMARDs like methotrexate to reduce prednisone doses and allow for earlier discontinuation of prednisone.
Methotrexate is considered a steroid-sparing treatment for many forms of arthritis such as giant cell arteritis, juvenile idiopathic arthritisrheumatoid arthritis, systemic lupus erythematosus, polymyalgia rheumatica, etc. Methotrexate is also commonly used as a steroid-sparing agent in the treatment of uveitis. Methotrexate may be a viable steroid-sparing agent for myasthenia gravisalthough azathioprine is better studied and more commonly used for this purpose.
A study demonstrated that patients with myasthenia gravis who are treated with methotrexate had significant improvement in disease activity and reduced prednisone dosages. Two studies demonstrated that lupus patients taking mycophenolate and voclosporin could achieve clinical response while using much lower doses of oral prednisone. In fact, these two trials had the lowest peak steroid doses and faster steroid tapering than any other lupus nephritis trial.
In patients with lupus without renal involvement, mycophenolate was shown to be superior to azathioprine when combined with steroids, and thus may be a better option than azathioprine for reducing prednisone doses. Mycophenolate can be used to reduce steroid use in many different inflammatory and immune diseases other than lupus. Mycophenolate has similar steroid-sparing effects as methotrexate when used for uveitis.
In a head-to-head study comparing mycophenolate and azathioprine for the treatment of pemphigus, patients taking mycophenolate required significantly lower steroid dose to achieve clinical remission compared to patients taking azathioprine. Mercaptopurine may be a great option to reduce prednisone doses in patients with inflammatory bowel disease.
The brand name of mercaptopurine is Purinethol. Azathioprine is another DMARD that can reduce steroid doses in patients with inflammatory bowel disease. It is often used along with infliximab for this purpose. Azathioprine may also be used to reduce the use of steroids in patients with myasthenia gravis. A study comparing methotrexate and azathioprine in patients with myasthenia gravis demonstrated that both drugs had a similar degree of steroid-sparing effects.
Azathioprine may also be effective at reducing the cumulative steroid dose in patients with giant cell arteritis, although data is mostly limited to case studies. Azathioprine may effectively lower the need for steroids in patients with recurrent pericarditis. In one study Leflunomide is an effective steroid-sparing agent for various kinds of arthritis.
In a small study, lower steroid doses were required in patients with polymyalgia rheumatica and giant cell arteritis after taking leflunomide. Leflunomide is also an effective steroid-sparing option for patients with pulmonary sarcoidosis. Another lung disease, chronic hypersensitivity pneumonitis cHPmay be treated with leflunomide in some cases. A study showed that leflunomide had a significant steroid-sparing effect—half of the patients discontinued prednisone entirely.
In patients with inflammatory diseases related to IgG4 antibodies collectively known as IgG4-related diseaseleflunomide can lower the cumulative dose of steroids needed to achieve and maintain remission. Adding leflunomide to steroid therapy can also shorten the time to complete response and maintain a longer duration of remission compared to steroids alone.
Natural remedies are not a replacement for prednisone, but they may work alongside prednisone to help fight inflammation. Antioxidants such as flavonoids and carotenoids protect tissue from damage by reactive oxygen species and other free radicals. They may have an even stronger effect when taken together. By preventing tissue damage, these antioxidants prevent unwanted inflammatory responses from occurring.
Other anti-inflammatory supplements such as omega-3 fatty acidszincand turmeric curcumin fight inflammation that is already present. They provide the building blocks of natural molecules our body needs to resolve inflammation. Avoid inflammatory foods such as margarine, corn oil, deep-fried foods, and processed food products to reduce inflammation. It is well known that refined sugar and simple carbohydrates like white four, white rice, and high fructose corn syrup contribute to chronic inflammation.
Replace these processed items with plant-based foods that are high in fiber, like fruits, vegetables, and whole grains. Staying hydrated helps our bodies clear out toxins.
When metabolic waste products and toxins accumulate in the body, they contribute significantly to inflammation. Perhaps the most obvious example of this effect is when dehydration leads to higher concentrations of uric acid, triggering a gout flare. Water also has a lubricating effect on joints. Synovial fluid provides a cushion at the joints to prevent bones from coming into contact.
When we become dehydrated our synovial fluid does not provide as much lubrication. A deficiency of synovial fluid can lead to damage and inflammation of the joints. According to a recent studypatients aiming to reduce inflammation should avoid long endurance exercise as it can contribute to chronic inflammation.
Instead, opt for moderately intense exercise with frequent resting periods. Another study in concluded that 20 minutes of moderate exercise is sufficient to produce an anti-inflammatory response. It is no secret that stress leads to many health problems. That is why rest and relaxation are key to lowering inflammation. Not sleeping enough has immediate pro-inflammatory effects.
A healthy lifestyle should include eight hours of regular sleep each night. See our guide to improving sleep. Chronic stress contributes to chronic diseases by contributing to inflammation.
During this state, the body releases stress hormones cortisol and adrenaline. It also releases pro-inflammatory molecules called cytokines. These molecules plan an important role in fighting off different forms of danger, but when they are chronically released into the body, they can wreak havoc. To combat chronic stresspractice yoga or some form of meditation. This could be as simple as writing your thoughts down in a journal, discussing your concerns with a friend, or taking a nature walk.
The first step to replacing prednisone is discussing alternatives with a healthcare provider. Prednisone should not be stopped abruptly or without medical advice. This is called a dose taper. Patients who have been on high doses or long courses of prednisone will need more gradual tapers.
The steroid-sparing agents discussed above help treat disease so that less prednisone is required to control symptoms. The lifestyle modifications and health information listed above may help mitigate disease systems, possibly allowing for lower doses of prednisone. Ask a doctor about the recommendations and alternatives in this article if you are interested in switching to a low dose prednisone or replacing prednisone with a different treatment.
Skip to main content Search for a topic or drug. Prednisone alternatives: What can I take instead of prednisone? Prednisone doesn't work for everyone. Dexamethasone, methotrexate, mycophenolate, mercaptopurine, azathioprine, and leflunomide are some prednisone alternatives. Get the full list here.
❿Alternative to prednisone
- Any alternatives for Prednisone • Johns Hopkins Arthritis Center
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Methylprednisolone and prednisone are both corticosteroid medications. They have similar effects on the body but differ in their available forms and some of the side effects they cause. Both medications reduce inflammationand people use them to relieve the symptoms of many health conditions, such as rheumatoid arthritis RAlupusand eczema. Methylprednisolone and prednisone are both corticosteroids. Corticosteroids can reduce inflammation in the body and relieve related symptoms, such as body pain, swelling, and stiffness.
Corticosteroids reduce inflammation by suppressing the immune system. They are a standard treatment for autoimmune conditions, which often cause inflammation in the body. Methylprednisolone and prednisone are both common medications that are similar in price. They can come in branded or generic forms. As with most drugs, the generic versions cost less but still comprise the same substances. Methylprednisolone is stronger than prednisone:. Prednisone is an oral medication that people take in the form of a tablet, liquid, or concentrated solution.
People will take between one and four doses a day depending on the medical condition and the effectiveness of the treatment. In many cases, a doctor will inject methylprednisolone into either the muscle or vein. However, for certain conditions, such as RA, they may sometimes inject methylprednisolone directly into a joint to reduce inflammation. Being injectable makes methylprednisolone easier than prednisone to provide in large doses.
Both prednisone and methylprednisolone are very strong medications. Doctors will try to use the lowest possible dosage that is effective, so they may increase or decrease the dosage during treatment.
People who stop taking them too quickly may notice side effects, such as:. As methylprednisolone and prednisone are both very potent, they can cause a range of side effects, including:. The side effects of prednisone can also include losing touch with reality. For this reason, doctors may prescribe methylprednisolone to someone with a risk of mental health conditions instead of prednisone to reduce the risk of psychosis.
Due to these side effects, doctors may avoid prescribing these corticosteroids. They may only recommend them if nonsteroidal anti-inflammatory drugs NSAIDs are not effective or if a person has severe inflammation.
Corticosteroids can interact with many other medications, including some nutritional supplements and alternative medicines, such as herbal remedies.
Before using corticosteroids, a person should tell their doctor about any other medications that they are taking. Corticosteroids have a widespread effect on the body. As a result, they can cause complications, some of which are severe. Taking corticosteroids for more than a month, which doctors consider long-term use, increases the likelihood of adverse effects occurring.
It is important to note that these drugs can reduce the activity of the immune system, which makes it harder for the body to fight infection.
Complications are more likely to affect people who have or have had certain medical conditions, such as:. Methylprednisolone and prednisone are corticosteroids that can have a significant impact on the body. They are effective medications for reducing inflammation. Both medications can produce a range of side effects and complications. Methylprednisolone is more potent than prednisone. Doctors can give methylprednisolone orally or through an injection, while prednisone is only available as an oral treatment.
Methylprednisolone may, therefore, be more appropriate for people with digestive issues that stop them from taking or fully absorbing oral drugs. A doctor will decide which medication is best in each situation. People should ensure that their doctor is aware of all their previous health conditions and current medications when discussing taking corticosteroids. Rheumatoid arthritis RA is an inflammatory disease that affects the joints and also produces symptoms throughout the body.
Find out more about how…. While researchers do not know exactly what causes rheumatoid arthritis RAthey do know that heredity plays a role. Learn more about RA and genetics…. Doctors use a combination of blood tests to help them diagnose rheumatoid arthritis.
Learn more about these tests and what else the diagnostic process…. Rheumatoid arthritis causes pain, swelling, and inflammation in joints and can affect organs throughout the body. Find out more here. The exact causes of rheumatoid arthritis are unclear, but researchers have identified several risk factors. Learn about 10 of these here. How to understand chronic pain What is behind vaccine hesitancy? The amazing story of hepatitis C, from discovery to cure New directions in dementia research Can psychedelics rewire a depressed, anxious brain?
Medical News Today. Health Conditions Discover Tools Connect. What is the difference between methylprednisolone and prednisone? Medically reviewed by Dena Westphalen, Pharm. Methylprednisolone vs. Share on Pinterest Methylprednisolone and prednisone reduce inflammation by suppressing the immune system. How do people take methylprednisolone and prednisone? Share on Pinterest People can take methylprednisolone orally or as an injection. Image credit: Anonymous, Side effects. Share on Pinterest Prednisone can cause dizziness and nausea.
Image credit: nlm, Drug interactions. Share on Pinterest People with high blood pressure are more likely to experience complications from taking corticosteroids. How we reviewed this article: Sources. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations.
We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles.
You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Share this article. Latest news Having a sense of purpose may help you live longer, research shows. Dementia vaccines: What are they, and when could they become available? Exercising between 8—11 am may be best for cardiovascular health. Cancer: Intravenous delivery may improve nanoparticle vaccine efficacy. Related Coverage. What are the symptoms of rheumatoid arthritis? Medically reviewed by Nancy Carteron, M.
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Deflazacort (Calcort--Shire) is an oral corticosteroid licensed for use in adults and children. When deflazacort first became available last year. They include methotrexate, Arava, and the anti-TNF drugs such as Enbrel, Humira, and Remicade. These are very strong drugs as well and must be. They include methotrexate, Arava, and the anti-TNF drugs such as Enbrel, Humira, and Remicade. These are very strong drugs as well and must be. Prednisalone/Prednisone is a broad spectrum, cheap, easily available immuno-suppressant. It has it's own side effects, but can be minimized under supervised. Deflazacort (Calcort--Shire) is an oral corticosteroid licensed for use in adults and children. When deflazacort first became available last year. I am sure that there will be long-term effects on my body. Will prednisone eventually kill me? I'm an asthma sufferer who was diagnosed after developing thyroid disease. Mycophenolate has similar steroid-sparing effects as methotrexate when used for uveitis. Doctors can give methylprednisolone orally or through an injection, while prednisone is only available as an oral treatment. Prednisone should not be stopped abruptly or without medical advice. Medical News Today.I have chronic asthma and have been on 20 mg of prednisone for more than 20 years. Is there another drug that can replace prednisone for this kind of long-term use?
Many people are stuck on prednisone for long periods of time. Unfortunately, it's unlikely that anything currently available could replace it completely, but some drugs are also sometimes used to reduce dependence on prednisone. These are very strong drugs as well and must be used with caution, but sometimes they can have good effects when taken in small amounts or as a short-term alternative to prednisone.
According to a study published in the July issue of the Journal of Allergy and Clinical Immunology , two Chinese herbal supplements - ASHMI and FAHF-2 - were seen to have some effects that were similar to those of prednisone on the signs and symptoms of asthma and food allergies, respectively.
Depending on the advice of your doctor, ASHMI might be a supplement you could try to ease both your asthma symptoms and your dependence on prednisone as a long-term therapy. Keep in mind that I am not a doctor and can't diagnose you here or tell you how these options would affect you. Always check with your doctor before taking any medication or herbal remedy. You should know: The answer above provides general health information that is not intended to replace medical advice or treatment recommendations from a qualified healthcare professional.
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